Everything about Conolidine alkaloid for chronic pain
Most not long ago, it's been identified that conolidine and the above derivatives act to the atypical chemokine receptor 3 (ACKR3. Expressed in similar locations as classical opioid receptors, it binds to a wide array of endogenous opioids. Unlike most opioid receptors, this receptor acts for a scavenger and isn't going to activate a next messenger